HERON presents at ISPOR Europe 2008
HERON is please to announce that this year Heron Health PVT presented a total of 17 abstracts at the International Society for Pharmacoeconomic and Outcomes Research (ISPOR) European conference in Athens (7th-11th November 2008). Among the 17 abstracts were 14 posters. Members from the UK and India office attended.
Podium Presentation: Update of results and outcomes of NICE single technology appraisals – Economic criticisms Karia R, Plested M, Cann K, Zwaferink H
As a follow-up to a previous ISPOR poster, Analyst Rina Karia and team sought to update the database with since published STAs as well as conduct further qualitative research and investigate the criticisms on the economic aspects of the submissions. Discrepancies between ICERs obtained by the manufacturer and the ERG group, and their impact on outcomes were discussed.
Podium Presentation: A Comparison of Reasons for Recommendation and Rejection in Four Health Technology Appraisal Systems: NICE, SMC, CADTH, and PBAC Cann K, Karia R, Plested M, and Samuels E
Analyst Kimberly Cann and team sought to identify the reasons underlying recent drug appraisal decisions in four countries (England/Wales, Scotland, Canada and Australia) where decisions differed between the agencies.
Podium Presentation: Role of Disease Specific Instruments in the Measurement of Health-related Quality of Life In Cancer Clinical Trials Narvilkar P, Mahajan A, Dimri S, Kumar R, and Sehgal M
Analyst Pashkar Narvikar and team assessed the type of instrument(s) used to measure health-related quality of life in published cancer clinical trials.
Poster: Trends in Research into Central Nervous System Disorders: the influence of an aging population. Lock K, Samuels E
Analyst Kevin Lock and Senior Analyst Dr Ebony Samuels expanded on observations described in a previous presentation (PMC53, ISPOR 2008) concerning the influence of genetic discoveries on the number of probable RCTs in Alzheimer’s disease (AD) and Huntington’s disease (HD).
Poster: Huntington’s Disease: where have we been? Samuels E, Stoddart S, Lock K, Karia R
Senior Analyst Dr. Ebony Samuels and team investigated the published research in Huntington’s disease, and see if the completion of the genome project has lead to the treatments for this genetically linked disorder, as expected.
Poster: Systematic review reliability: sensitivity and specificity of one vs. two reviews. Muston, D; Alnwick, K
Head of Scientific Affairs Dominic Muston and Senior Analyst Kym Alnwick discussed the way in which a second abstract review by a different reviewer improves the quality of a systematic review of literature. This was done by fitting a statistical model to determine between-reviewer and between-review reliability and variation.
Poster: The Reimbursement of Orphan Drugs across Europe Nixon, F
Analyst Frances Nixon compared orphan drug policies and examined the reimbursement of orphan drugs across Europe.
Poster: What proportion of diseases are QALYs an irrelevant measure for? Proudfoot C, Alnwick K
Senior Analysts Claire Proudfoot and Kym Alnwick sought to clarify the extent to which lack of utility data, which is required to calculate QALYs and is not available for some drug indications, is a problem.
Poster: Categorizing research: where is the focus? Samuels E, Plested M
Senior Analysts Dr. Ebony Samuels and Melanie Plasted explored the proportion of research being conducted as randomized controlled trials (RCTs), observational studies (OS), systematic reviews (SR), or economic studies (ES) and assess the relative proportions of each across time.
Poster: Inappropriate sedation in ICUs: evidence from the literature? Jackson D, Proudfoot CW, Knight CJ, Cann K, Lock K
Working in collaboration with GE Healthcare, Senior Analyst Claire Proudfoot and team sought to establish the extent to which inappropriate sedation (both over and under) is reported as a problem in ICUs through a systematic review of the literature.
Poster: Impact of ICU sedation practice on patient morbidity, cost and hospital resource use: a systematic review Jackson D, Proudfoot CW, Knight CJ, Cann K, Lock K
Working in collaboration with GE Healthcare, Senior Analyst Claire Proudfoot and team sought to further establish the impact of improvements or changes in sedation practice, such as the introduction of guidelines, reinforcement of protocols, or practices such as daily interruption of sedation, on outcomes including mortality, morbidity and hospital costs and resource use.
Poster: Has the quality of Randomised Controlled trials increased with time: an analysis of data from 5 systematic reviews? Proudfoot C, Stoddart S, Muston D
Senior Analyst Claire Proudfoot and team discuss how the quality of studies included in systematic reviews is associated with the publication year of those studies.
Poster: Design and Reporting Trends in Piggy-Back Economic Trials
Ubhadiya BS, Gautam C, Narvilkar P, Singh N, Bhanderi M, Dimri S
Analyst Bhavesh Ubhadiya and team assessed trends in the prevalence and type of economic analysis alongside randomised controlled trials published between 1997 and 2007.
Poster: Pharmacogenomics: Relevance And Applicability In Post-Genomic Era (HIV-Therapy) Chawla A, Kumar R, Aneja G, Mayank B, Sehgal M
Analyst Abhineet Chawla and team established the relevance between the available knowledge of the pharmacogenomic variation in individuals and its current application in clinical trial setup as epitomised by HIV therapy drugs.
Poster: Socio-economic impact of avian influenza in south-east asia and neighbouring high risk countrieds Arora M, Srivastava K, Siddiqui MK, Verma J, Ahuja M, Sharma S
Analyst Manish Arora and team reviewed of the scientific literature from 1995 to the present of the socio-economic impact of avian influenza in South-East Asian nations and neighbouring high risk countries.